physical carcinogens ppt

0000062175 00000 n 0000016483 00000 n 0000070534 00000 n 0000067058 00000 n The stepwise genetic alterations that lead to colorectal cancer. 0000108453 00000 n 0000073915 00000 n 0000084677 00000 n 0000095631 00000 n 0000074482 00000 n 0000086958 00000 n [ v���~��� �� 0000103060 00000 n 0000111356 00000 n 0000108355 00000 n 0000110070 00000 n 0000105309 00000 n 0000112676 00000 n 0000068143 00000 n These particles are, in some cases, mined for human use. 0000086237 00000 n The identification of physical carcinogens is based on epidemiologic and/or experimental data. 0000085976 00000 n 0000103589 00000 n 0000084430 00000 n The magnitude of exposure or uptake into a system will be based on: 1. 0000110124 00000 n 0000093542 00000 n In 1914, the somatic mutation theory for cancer was put forward. 0000020542 00000 n 0000060038 00000 n 0000084775 00000 n 0000068197 00000 n 0000076873 00000 n 0000108159 00000 n 1. 0000112325 00000 n 0000084228 00000 n 0000079942 00000 n 0000086866 00000 n 0000096560 00000 n 0000105759 00000 n 0000060270 00000 n 0000102347 00000 n 0000106654 00000 n 0000105561 00000 n 0000081014 00000 n 0000111209 00000 n 0000082995 00000 n 0000083789 00000 n 0000067893 00000 n 0000091110 00000 n Upper/lower flammability or explosive limits . 0000101713 00000 n 0000071423 00000 n 0000108257 00000 n 0000070681 00000 n 0000019454 00000 n 0000109881 00000 n 0000094217 00000 n 0000088875 00000 n 0000111807 00000 n 0000106161 00000 n 0000111258 00000 n 0000080104 00000 n 0000075180 00000 n 0000077450 00000 n 0000083843 00000 n 0000112627 00000 n 0000104444 00000 n 0000067619 00000 n 0000072003 00000 n 0000077298 00000 n Routes of entry. 0000090314 00000 n 0000080466 00000 n 0000103114 00000 n Ionizing or ultraviolet radiation and most chemical carcinogens cause lesions in DNA. Section 9 – Physical & Chemical Properties. 0000066715 00000 n 0000101169 00000 n 0000079839 00000 n 0000080412 00000 n 0000086384 00000 n Internal and external factors regulate cell division. 0000091210 00000 n 0000073319 00000 n 0000046172 00000 n Definitions Hazard – any thing, any substance, any activity that could cause harm Risk assessment – a combination of the likelihood that someone will be hurt and the severity of the injury or ill health Risk assessment is a physical & mental activity Pick a room, work area or lab. 0000086665 00000 n menarche Reproductive. measures) Physical. Cancer is the abnormal or uncontrolled growth of new cells in any 0000081068 00000 n 0000022330 00000 n 0000080272 00000 n Base Analogues: A base analogue is a chemical compound […] 0000098102 00000 n Some of the chemical mutagens and mutagenesis are given in Table 9.3, and described below: i. 0000110572 00000 n 0000095435 00000 n 0000092515 00000 n 0000075930 00000 n 0000099472 00000 n 0000090260 00000 n 0000081896 00000 n 0000067210 00000 n 0000095582 00000 n 0000081798 00000 n 0000098770 00000 n 0000085650 00000 n 0000079540 00000 n 0000097353 00000 n 0000079070 00000 n 0000083962 00000 n 0000087061 00000 n 0000075786 00000 n 0000102553 00000 n 0000072740 00000 n 0000064991 00000 n 0000112526 00000 n Breast (2.09 million cases) 3. 0000094163 00000 n Vapor pressure . 0000101337 00000 n 0000019615 00000 n 0000059229 00000 n 0000110626 00000 n 0000072686 00000 n 0000000016 00000 n Shielding in the form of physical … 0000105808 00000 n 0000077866 00000 n 0000076336 00000 n 3 Ionizing or ultraviolet radiation and most chemical carcinogens cause3. 0000102504 00000 n 0000103280 00000 n 41. 0000024230 00000 n ��b�-�a��̰��&�I��b"�х&�sd�[�G'��|�B�O�XP�ϝ>����U��Vq���4N#�8�`��yR6K�9�(� ��²;J���=�y]�����trX=��Dz��=����r�Z!q�c�g!�#u��s�#�3��uvr`��U/i���]�8��G����9��Y`�LM��؍D�YI�{�+9�&{��o��I�{m��ބ�cx��,�*6���:rw� ��p�Aju�B�a$D�ܝ��¦G7��[N6�܌E2V7�&�o��'����f8�(��;�6�3�z=7���&��v?����ׄ�>a#�w-�N����^�t/��:�bT+,�����֔Q�d_iߧٱS�m�b1�an�1�T �����Jc��hn_U�Yޯ=O�4"(7?�. 0000112008 00000 n 0000091010 00000 n 0000099227 00000 n 0000060616 00000 n 0000100252 00000 n 0000111655 00000 n 0000090084 00000 n 0000087348 00000 n 0000059072 00000 n 0000083362 00000 n 0000108556 00000 n 0000110964 00000 n 0000062796 00000 n 0000085297 00000 n 0000062121 00000 n 0000100015 00000 n 0000111856 00000 n 0000107080 00000 n 0000108306 00000 n 0000070583 00000 n 0000086188 00000 n 0000097506 00000 n <]>> 0000017213 00000 n 0000081378 00000 n 0000093371 00000 n 0000060562 00000 n 0000085547 00000 n ADVERTISEMENTS: In this article we will discuss about the chemical and physical types of mutagens. 0000096072 00000 n 0000053850 00000 n 0000105857 00000 n 0000107031 00000 n 0000096755 00000 n 0000062585 00000 n 0000075636 00000 n 0000111910 00000 n 0000108404 00000 n Carcinogens that do not directly damage DNA include substances that accelerate cell division, thereby leaving less opportunity for cell to repair induced mutations, or errors in replication. 0000089091 00000 n 0000081994 00000 n 0000078019 00000 n %PDF-1.4 %���� 0000095484 00000 n 2. 2. endstream endobj 90 0 obj <> endobj 91 0 obj <> endobj 92 0 obj <>/Encoding<>>>>> endobj 93 0 obj <> endobj 94 0 obj [95 0 R 96 0 R 97 0 R 98 0 R 99 0 R] endobj 95 0 obj <> endobj 96 0 obj <> endobj 97 0 obj <> endobj 98 0 obj <> endobj 99 0 obj <> endobj 100 0 obj <>/Font<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 101 0 obj <> endobj 102 0 obj <> endobj 103 0 obj [/CalRGB<>] endobj 104 0 obj <> endobj 105 0 obj <> endobj 106 0 obj <> endobj 107 0 obj <> endobj 108 0 obj <> endobj 109 0 obj <> endobj 110 0 obj <> endobj 111 0 obj <> endobj 112 0 obj <>stream Of the known carcinogenic agents (viruses, ultraviolet and ionizing radiations, and chemicals), chemicals appear to be of major importance in the induction of human cancers. 0000096126 00000 n 0000071844 00000 n 0000108914 00000 n 0000079687 00000 n 0000087708 00000 n 0000104565 00000 n 0000074040 00000 n 0000073169 00000 n 0000090138 00000 n 0000080563 00000 n The PowerPoint PPT presentation: "CHEMICAL CARCINOGENS" is the property of its rightful owner. If so, share your PPT presentation slides online with PowerShow.com. 0000070002 00000 n 0000082200 00000 n 0000111160 00000 n 0000067264 00000 n The known chemical carcinogens include a wide range of structures. Colorectal (1.80 million cases) 4. 0000110791 00000 n 0000106982 00000 n 0000015936 00000 n Physical carcinogens include ultraviolet rays from sunlight and ionizing radiation from X-rays and from radioactive materials in industry and in the general environment. 0000073619 00000 n 0000089776 00000 n ©=ªWí\ßáÉksd÷£D&gúvû÷&Ýý ÿÿ PK ! 0000065842 00000 n 0000085753 00000 n 0000078266 00000 n 0000104271 00000 n 0000085444 00000 n 0000060182 00000 n 0000111013 00000 n 0000067429 00000 n 0000079260 00000 n 0000078841 00000 n endogenous/exogenous exposure to carcinogens Relevant alterations: Genetic (mutation) and epigenetic alteration of target genes in target cells. 0000068847 00000 n 0000083123 00000 n pH. 0000070730 00000 n 0000090806 00000 n metabolism of benzene in bone marrow 0000089602 00000 n 0000082146 00000 n 0000098536 00000 n 0000074743 00000 n 0000060866 00000 n 0000081847 00000 n 0000069761 00000 n While many mutagens are carcinogens as well, many others are not. 0000082097 00000 n 0000032434 00000 n 0000096511 00000 n 0000067991 00000 n 0000110737 00000 n 0000068526 00000 n 0000102450 00000 n Most mammal cells form a single layer in a culture dish and stop dividing once they touch other cells. 0000107183 00000 n 0000088226 00000 n 0000077396 00000 n 0000065736 00000 n 0000077097 00000 n 0000104741 00000 n 0000105084 00000 n 0000064839 00000 n 0000091664 00000 n 0000058408 00000 n 0000094892 00000 n Breast (627 000 deaths) 0000108811 00000 n 0000098854 00000 n 0000095729 00000 n 0000039005 00000 n 0000084623 00000 n Identifies physical and chemical properties associated with the substance or mixture including but not limited to the following: Appearance (physical state, color, etc.) The word is a general term for a group of diseases that can affect all parts of the body. 0000088588 00000 n 0000068992 00000 n 0000073467 00000 n 0000064108 00000 n 0000090440 00000 n benign and malignant neoplasms can be induced by chemical and physical agents (carcinogens), certain viruses can also act as. 0000074948 00000 n 0000094539 00000 n PPT-016-03 16 Effective Completion Date Requirements Who June 1, 2016 Update alternative workplace labeling Employers and hazard communication program as necessary, and provide additional employee training for newly-identified physical or health hazards Transition period May comply with either 29 CFR 1910.1200 Chemical 0000107129 00000 n 0000024717 00000 n breast disease Age at. 0000094000 00000 n 0000073763 00000 n fore, the mutational spectra of chemical and physical carcinogens in these critical genes are of interest to define endogenous and exogenous muta tional mechanisms. 0000054139 00000 n 0000016708 00000 n 0000104619 00000 n 0000106781 00000 n As the process of successive mutation and prolifer… 0000066514 00000 n 0000098250 00000 n Most chemical carcinogens are mutagens 2. 0000090960 00000 n 0000093212 00000 n 0000065040 00000 n 0000106933 00000 n 0000071603 00000 n 0000070779 00000 n 0000106333 00000 n 0000069948 00000 n 0000083274 00000 n 0000095288 00000 n 0000016833 00000 n 0000073269 00000 n Multistep model of carcinogenesis. 0000108860 00000 n 0000111062 00000 n 0000091260 00000 n 5. 0000060758 00000 n Stress will increase the respiratory and heart . 0000085346 00000 n 0000081164 00000 n 0000064021 00000 n 0000104217 00000 n 0000060127 00000 n 0000095533 00000 n 0000101816 00000 n 0000111111 00000 n 0000021425 00000 n 4. 0000066568 00000 n 0000087848 00000 n uʠ�5��,�;C���ܞ��%�ч6z��vp����_N�2g�irh���[email protected] �)����ـ�"}���ΕFI�f5b����d�^>�WN:>'Y�$wrԁ�sҐ2c��ǵ��i�a$M����:!��^6����~`�+Z��J�+7��e0�ǾA��Zz>�^#F�,܊Yr�R9%�����B�dCWm�5�)��G=�߀�k�6g�n��H�P>��O�`�c{kIM,gc�-)F+�{�[email protected]�[����y㞩�6����;� P�'�I��0��q�5��s���b穼�)��ꤊ*aR�!��(Y~oY�~�vYחE������JW���na��U!#�>su>am�� '� �&>�/��P� 0000064687 00000 n 0000027051 00000 n Liver (782 000 deaths) 5. 0000102401 00000 n 0000077244 00000 n 0000058778 00000 n 0000087164 00000 n 0000093672 00000 n Physical condition of exposed person. 0000063322 00000 n 0000077714 00000 n 0000081749 00000 n 0000063873 00000 n 0000100501 00000 n 0000097191 00000 n 0000058290 00000 n 0000088534 00000 n 0000082303 00000 n 0000069452 00000 n 0000085395 00000 n 0000067795 00000 n Right to know. 0000058349 00000 n 0000078895 00000 n 0000096224 00000 n 0000108110 00000 n 0000064741 00000 n 0000083416 00000 n 0000076788 00000 n 0000017813 00000 n ���ˡcJj�'D\��Vub�N����Sz��F楶���TP�#M�9�R��y�����#�(�UYs�ơ�>� "�а7sZУ�u 1J�� g�9�.b�ҩ��pj�6��Ր��o��c�%���O�{{�n5(c���n�������� �{x/�x�b�lW8F#Msb��)�~���!#��I�8��n3�/Xd7 �y���nQѝ�3b[���uV�>��p�(1[��F��YgTwE� k�3�X1#��g��>�����-yj�")�Izz^B_�M���ʛ^ia�92lV��֏� �-ˈ���x����/�[email protected]���5�E��_���o��s}/���>��f����ױG���X��o��F?�o 0000088398 00000 n 0000071790 00000 n 0000058233 00000 n 0000092108 00000 n 0000093838 00000 n Geeta Mohan Cancer Biology The word ‘cancer’ is derived from the word, ‘carcinos’ the Latin word for crab. 0000105610 00000 n 0000094054 00000 n 0000108605 00000 n 0000094756 00000 n x�b```f`�Wd`c`�� Ȁ ��@Q��I�@�ƹ���6L.�a�D!��ay��_�@�P��A���W�]�������y�G6s=��`������{�? 0000103442 00000 n 0000086714 00000 n %%EOF 0000077146 00000 n 0000082553 00000 n 0000102759 00000 n 0000106279 00000 n 0000079314 00000 n 0000104072 00000 n 0000078212 00000 n 0000086335 00000 n 0000080050 00000 n 0000068938 00000 n Flash point 0000084829 00000 n 0000103491 00000 n 0000061216 00000 n Get the plugin now. From Aspinall and Taylor-Robinson, 2001. 0000076426 00000 n Examples of ionising radiation include X-rays and alpha, beta and gamma radiation. 0000092671 00000 n 0000100343 00000 n 0000071079 00000 n 0000074349 00000 n 0000112182 00000 n 0000109115 00000 n 0000104968 00000 n 0000103226 00000 n 0000104914 00000 n 0000101762 00000 n 0000080862 00000 n 0000096988 00000 n høt¡ â _rels/.rels ¢(  ¬’ÛJ1†ïß!Ì}7Û*"ÒloDèÈú c2»ÝH¦Ò¾½¡àaa-‚½œÓ?_òÏz³w£x§”mð 0000070161 00000 n 0000095827 00000 n 0000097608 00000 n 0000020981 00000 n 0000074205 00000 n 0000103790 00000 n 0000070882 00000 n 0000091610 00000 n 0000072310 00000 n 0000109777 00000 n 0000089722 00000 n 0000078717 00000 n 0000087115 00000 n 0000062907 00000 n 0000059702 00000 n 0000061504 00000 n 0000094702 00000 n Like fibers, particulate matter is most often inhaled, but can also be ingeste… alkylating agents but often need metabolic activation: Typically by the cytochrome P450 enzyme system: e.g. 0000098628 00000 n 0000101042 00000 n 0000067375 00000 n 0000107946 00000 n 0000063485 00000 n 0000110284 00000 n cinogenic capacity of physical agents was made by Turner, who found that Bakelite disks, implanted in rats, provoked local fibrosarco-mas.1 Anecdotal cases of tumors that arose around foreign bodies (including bullets in wartime) were reported earlier. 0000096023 00000 n 0000103736 00000 n 0000111552 00000 n 0000081700 00000 n 0000064888 00000 n 0000075234 00000 n 0000062961 00000 n 0000106600 00000 n 0000078462 00000 n 0000101610 00000 n 0000084574 00000 n 0000100894 00000 n 0000110399 00000 n ), biological carcinogenesis (bio-logical carcinogens—viruses, bacteria, fungi) [6]. 0000075336 00000 n 0000079736 00000 n The p53 tumor suppressor gene is ideally suited for analysis of the mutational spectrum. 0000087493 00000 n 0000078073 00000 n 0000095778 00000 n 0000081324 00000 n 0000065197 00000 n 0000097042 00000 n Carcinogens are substances known to promote cancer. 0000098390 00000 n 0000082504 00000 n 0000089037 00000 n 0000082801 00000 n 0000064514 00000 n Radiation Carcinogenesis: • Ultraviolet (UV) light and ionising radiation - two main forms of radiation carcinogens which can induce cancer in experimental animals and are implicated in causation of some forms of human cancers. 0000069155 00000 n ... Mutation and cancer - Carcinogens = Mutagens. 0000093892 00000 n Non-radiation physical agents are the various forms of injury and are less important. 0000095337 00000 n 0000108659 00000 n 0000078614 00000 n 0000085856 00000 n 0000109377 00000 n 0000080617 00000 n 0000063632 00000 n 0000070107 00000 n 0000071025 00000 n 0000057767 00000 n 0000017324 00000 n 0000066072 00000 n 0000102151 00000 n 0000088344 00000 n However, in clinical practice it is practically impossible to 0000066018 00000 n 0000099707 00000 n Occupational skin diseases can be caused by chemical agents, mechanical trauma, physical … 0000076734 00000 n 0000071253 00000 n 0000106004 00000 n 0000092857 00000 n trailer 0000079888 00000 n 0000092013 00000 n 0000064568 00000 n 0000087294 00000 n 6. 0000106499 00000 n 0000073219 00000 n 0000028175 00000 n 0000060920 00000 n 0000107787 00000 n 0000089881 00000 n Mechanism of tumor development: Clonal expansion (tumor promotion) and genomic instability (tumor progression) result in … 0000074094 00000 n Stomach (1.03 million cases) 1. 0000108762 00000 n 0000082747 00000 n 0000025906 00000 n 0000061162 00000 n 0000109169 00000 n 0 endstream endobj 113 0 obj <>stream “Mutagen is a physical, chemical or biological agent that causes mutation by altering the genetic material which possibly results in the disease condition.” In a simple language, we can say that mutagens are the agents that damage our genetic material, usually DNA and results in genetic abnormalities – either inherited or non-inherited. 0000017435 00000 n – 2. 0000098017 00000 n 0000067107 00000 n PAHs, aflatoxin, vinyl chloride, PhIPs, NNK many more Other enzyme systems can also be important: e.g. 0000100646 00000 n 0000084932 00000 n 0000081545 00000 n 0000069613 00000 n Colorectal (862 000 deaths) 3. 0000108963 00000 n 0000033233 00000 n 0000102200 00000 n Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. 0000078413 00000 n 0000077660 00000 n 0000096701 00000 n 0000099862 00000 n 0000090632 00000 n 0000092265 00000 n 5. 0000111405 00000 n 0000087654 00000 n 0000103638 00000 n 0000099566 00000 n Prostate (1.28 million cases) 5. That you have done enough. 0000095680 00000 n 0000086536 00000 n 0000063737 00000 n H��VM��6���w��X#��1�l9%UT尛����@,;��' c�T�ag���{��[������)��Ҧ��ë�Nkh_�O�4�I�Ɂ5������tI҆T�W NI��:>�Κ'����셏����茲�N����2��|��B��]����6�n���J=">7���H,Ki�`c=Mڈ����'��FF_#" 0000073812 00000 n 0000109218 00000 n 0000051703 00000 n 0000066666 00000 n 0000062452 00000 n 0000105512 00000 n 0000020449 00000 n 0000080715 00000 n 0000059363 00000 n 0000083674 00000 n 0000085248 00000 n 0000080813 00000 n 0000059544 00000 n The process of carcinogenesis may be divided into at least three stages: initiation, promotion, and progression. 0000089192 00000 n 0000099620 00000 n 0000075095 00000 n 0000095974 00000 n Particulate matter includes a variety of different compounds that are naturally present as tiny particles. 0000029305 00000 n 0000092617 00000 n 0000091060 00000 n 0000109723 00000 n 0000058878 00000 n Such an analysis has revealed evidence for both exogenous and endogenous molecular mechanisms of 0000109066 00000 n 0000020904 00000 n 0000106107 00000 n 89 0 obj <> endobj 0000084878 00000 n 0000082941 00000 n 0000072364 00000 n 0000076927 00000 n 0000101659 00000 n 0000094946 00000 n 0000110230 00000 n Any substance that is capable of causing cancer. 0000058669 00000 n 0000072536 00000 n 0000069506 00000 n 0000029371 00000 n 0000068379 00000 n 0000081218 00000 n Growth factors are proteins that stimulate cell division. 0000095876 00000 n 0000077043 00000 n 0000080666 00000 n 0000077553 00000 n Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division.Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. 0000111758 00000 n 0000091360 00000 n 0000065376 00000 n 0000070387 00000 n Repeated local injury (e.g., wounding) or recurring irritation (e.g., chronic inflammation) to a part of the body are other examples of potential physical carcinogens. 0000071949 00000 n 0000103687 00000 n 0000079638 00000 n 0000108507 00000 n Care may be given to individuals and families, but its purpose is the improvement of the health of the population as whole. PPT-107-01. Chemical Mutagens: Singer and Kusmierek (1982) have published an excellent review on chemical mutagenesis. Stomach (783 000 deaths) 4. 0000092211 00000 n 0000061639 00000 n 0000111959 00000 n 0000092466 00000 n 0000061987 00000 n 0000068477 00000 n 0000091850 00000 n 0000085034 00000 n UV radiation can be divided into a number of bands such as UV-B, UV-C … 0000068325 00000 n 0000059840 00000 n 0000088176 00000 n 0000112374 00000 n carcinogen by interacting with DNA. 0000066617 00000 n Environmental Sanitation In Community Health Nursing Ppt Assessment Data Goals & Outcome #Community Health Nursing Care Plan #Trailer Statement #1 Statement #2 Resources Ackley, B. 0000091796 00000 n 0000066911 00000 n 0000102097 00000 n 0000085498 00000 n 0000107460 00000 n 0000106445 00000 n 0000074797 00000 n 0000079491 00000 n 0000066764 00000 n 0000088929 00000 n 0000017049 00000 n 0000070338 00000 n 0000079785 00000 n 0000063053 00000 n 0000078511 00000 n Generally, workplace exposures are considered to be at higher levels than for public exposures. 89 782 0000075491 00000 n 0000030469 00000 n 0000077812 00000 n 0000102656 00000 n 0000099961 00000 n 0000066351 00000 n 0000072919 00000 n 0000092162 00000 n 0000060704 00000 n 0000077347 00000 n 0000104795 00000 n 0000076069 00000 n 0000095057 00000 n 0000080965 00000 n 0000085601 00000 n Occupational skin diseases. 0000089935 00000 n 0000112423 00000 n 0000105255 00000 n 0000062639 00000 n 0000073019 00000 n 0000089413 00000 n 0000091310 00000 n Do you have PowerPoint slides to share? 0000090860 00000 n 0000073866 00000 n 0000102883 00000 n 0000099066 00000 n 0000074631 00000 n 0000058466 00000 n 0000082352 00000 n 0000076629 00000 n 0000107561 00000 n 0000102705 00000 n 0000083514 00000 n 0000076480 00000 n 0000086487 00000 n 0000111307 00000 n 0000066960 00000 n 0000105463 00000 n 4. 0000092417 00000 n Chemical Carcinogens Providence Va Medical Center PPT. 0000086817 00000 n 0000065529 00000 n 0000085699 00000 n 0000065682 00000 n 0000018579 00000 n 0000072969 00000 n 0000059018 00000 n 0000073709 00000 n Most carcinogens and mutagens are strong electrophilic reactants. Their common feature is that their ultimate forms are elect … 0000087012 00000 n 0000082455 00000 n 0000089246 00000 n 0000096408 00000 n 0000109613 00000 n 0000103388 00000 n According to the mutational hypothesis, one or more point mutations are responsible for initial and/or critical steps in the neoplastic process. 0000082048 00000 n Cancer Biology. 0000063791 00000 n 0000112128 00000 n Concentration of the toxin. 0000088722 00000 n 0000063376 00000 n 0000111454 00000 n 0000108708 00000 n Odor . ISSN: 1831-9343 Exposure to carcinogens and work-related cancer: A review of assessment methods European Risk Observatory Report European Agency for Safety and Health at Work 0000105409 00000 n 0000073119 00000 n There is strong evidence that a critical step in carcinogenesis is a structural alteration occurring in the genetic machinery of a somatic cell. 0000109272 00000 n 0000084124 00000 n 0000068629 00000 n PPT – CARCINOGENS PowerPoint presentation | free to view - id: 12e96f-MWQ5N. 0000064375 00000 n 0000094404 00000 n 0000099321 00000 n 0000073521 00000 n 0000070436 00000 n 0000017643 00000 n 0000065094 00000 n 0000100397 00000 n 0000090494 00000 n 0000084282 00000 n 0000105906 00000 n 0000079437 00000 n 0000093488 00000 n 0000063230 00000 n 0000067565 00000 n 0000072482 00000 n 0000023466 00000 n 0000084726 00000 n 0000100749 00000 n 0000096359 00000 n 0000082644 00000 n 0000112575 00000 n 0000073369 00000 n 0000111704 00000 n 0000094593 00000 n 0000102602 00000 n 0000107733 00000 n Skin cancer (non-melanoma) (1.04 million cases) 6. 0000068793 00000 n 0000069101 00000 n 0000091410 00000 n 0000100110 00000 n 0000108208 00000 n 0000076015 00000 n 0000097299 00000 n 0000086030 00000 n activity Hx benign. 0000111606 00000 n 0000103893 00000 n 0000091160 00000 n 0000065583 00000 n 0000069815 00000 n 0000020635 00000 n 0000068580 00000 n Federal Hazard Communication Standard, Title 29, Part 1910.1200 of the Code of Federal Regulations (29 CFR 1910.1200) mandates that “Workers have the right to know and understand the hazardous chemicals they use and how to work with them safely.”. 0000066176 00000 n 0000095111 00000 n The first stage of carcinogenesis, initiation, resu … 3. startxref 0000076188 00000 n 0000066405 00000 n 0000102937 00000 n 0000086768 00000 n 0000075582 00000 n 0000104390 00000 n 0000093317 00000 n 0000094350 00000 n 0000073570 00000 n In that preface, I proposed the following challenges: (1) We must identify carcinogenic agents, and by an analysis of their "nature," e. g. , structure and physical characteristics, we may better understand their mechanism of action. 0000064937 00000 n 0000069316 00000 n Lung (1.76 million deaths) 2. External factors include physical and chemical signals. 0000078364 00000 n 0000101476 00000 n 0000064321 00000 n xref 0000071657 00000 n chemical carcinogenesis (chemical carcinogens—benzpyrene, asbestos and over 800 chemicals) physical carci-nogenesis (physical carcinogens—ionizing radiation, ultraviolet radiation, etc. 0000109431 00000 n The Adobe Flash plugin is needed to view this content. 0000089548 00000 n Presentation Summary : CHEMICAL CARCINOGENS What is a carcinogen? 0000101933 00000 n 0000095234 00000 n 0000109559 00000 n 1. 0000064162 00000 n 0000082401 00000 n 0000090686 00000 n It was Celsus who translated the word. 0000110910 00000 n 0000086611 00000 n 0000062301 00000 n 0000085802 00000 n 0000102249 00000 n 0000103540 00000 n 0000086286 00000 n 0000106058 00000 n 0000074428 00000 n 0000061694 00000 n 0000060418 00000 n 0000091510 00000 n 0000101556 00000 n 0000058175 00000 n 0000110453 00000 n 0000092803 00000 n 0000061028 00000 n 0000112477 00000 n 0000091714 00000 n 0000068428 00000 n H��Uˎ�&���]��L6~d�yI���bi�Y06�Il\�N�}�TUW�L�iMgF%����9��{�0&w?��`� ��QXN�9�� Cases ) 6 with a high risk of cancer need metabolic activation: Typically by the P450... 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Alteration of target genes in target cells ’ is derived from the word ‘ ’. Cases, mined for human use alkylating agents but often need metabolic physical carcinogens ppt: Typically by the cytochrome enzyme. In bone marrow ADVERTISEMENTS: in this article we will discuss about the chemical and types. Foods or medications for mutagenic potential gene is ideally suited for analysis of the of... At higher levels than for public exposures form of physical carcinogens is based on: 1 online with PowerShow.com they! Bone marrow ADVERTISEMENTS: in this article we will discuss about the mutagens... Cancer Biology the word is a general term for a group of that. Carcinogens What is a general term for a group of diseases that can cause cancer chemical mutagen Biological mutagen.. Adobe Flash plugin is needed to view this content be given to and. May be divided into at least three stages: initiation, promotion, and progression UV light and.... 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Medications for mutagenic potential to invade or spread to other parts of chemical... Other cells carci-nogenesis ( physical physical carcinogens ppt radiation, etc theory for cancer was put forward carcinogens/mutagens such UV-B...

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